Run Destination Not Valid For Running Scheme Xcode

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happened the same to me with a project I downloaded. In my case, the solution was to change the “Base SDK” to the latest OS X in the Build Settings.

To do so, click on the project name in the navigator on the left, then on Build Settings and in the main window you should look for Base SDK.

If Base SDK does not show, ensure that “All” is selected in the filter at the top of the page.

Base SDK set to 10.10 in this example